- Sand Gravel & Aggregate, Le Claire
- Sandwich Shop Restaurants, Le Claire
- Seafood Restaurants, Le Claire
- Sewing & Yarn Stores & Supplies, Le Claire
- Sewing Machines, Equipment & Supplies, Le Claire
- Ship & Boat Building & Repairing, Le Claire
- Shopping & Shopping Services, Le Claire
- Siding Contractors, Le Claire - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
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- Small Appliances, Le Claire
- Snack Foods, Le Claire
- Snacks & Desserts, Le Claire
- Social Services & Welfare, Le Claire
- Specialty Stores, Le Claire
- Stone, Le Claire
- Stone & Rock Quarry, Le Claire - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Submarine Sandwich Restaurants, Le Claire
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