- Sandwich Shop Restaurants, Orange City
- Satellite TV Service, Orange City
- Scrapbooks & Scrapbook Supplies, Orange City
- Screen Printing, Orange City
- Secondary Schools, Orange City
- Security Brokers & Dealers, Orange City
- Seed Companies, Orange City
- Seeds & Bulbs Wholesale & Growers, Orange City
- Septic Tank Installation & Repair, Orange City - Septic Systems
- Septic Tank Pumping & Cleaning, Orange City - Septic Systems
- Septic Tanks & Septic Systems Contractors, Orange City - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewer & Drain Cleaning & Repair, Orange City - Drain Cleaner & Installation Services
- Sheriff's Department, Orange City
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- Shopping & Shopping Services, Orange City
- Siding Contractors, Orange City - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Skin Care & Cosmetology Salons, Orange City
- Skin Care Products & Treatments, Orange City
- Social Services & Welfare, Orange City
- Societies & Foundation Associations, Orange City
- Speciality Food Stores, Orange City
- Specialty Animal Services, Orange City
- Specialty Stores, Orange City
- State Government, Orange City
- Stocks & Bond Brokers, Orange City
- Submarine Sandwich Restaurants, Orange City
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