- Sandwich Shop Restaurants, Altoona
- Satellite Dish Antennas & Equipment Dealers, Altoona
- Satellite TV Service, Altoona
- Savings & Loan Associations, Altoona
- Savings Banks, Altoona
- Seafood Restaurants, Altoona
- Secondary Schools, Altoona
- Security & Commodity Brokers, Altoona
- Security Brokers & Dealers, Altoona
- Sheet Metal Contractors, Altoona - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Altoona
- Shoe Stores, Altoona - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Altoona
- Siding Contractors, Altoona - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Altoona
- Sitting Services, Altoona
- Sleep Disorders Treatment & Information Centers, Altoona
- Smoked Meat Restaurants, Altoona
- Snacks & Desserts, Altoona
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- Snow Removal Services, Altoona - Snow Plow Service
- Social Clubs & Organizations, Altoona
- Social Services & Welfare, Altoona
- Societies & Foundation Associations, Altoona
- Special Dies Tools Jigs & Fixtures Manufacturers, Altoona
- Specialty Stores, Altoona
- Sporting Goods Stores, Altoona
- Sports Bars & Lounges, Altoona
- Stainless Steel Fabricating Manufacturers, Altoona
- State Government, Altoona
- Stationery & Office Supplies, Altoona
- Steak House Restaurants, Altoona
- Steel Manufacturers, Altoona
- Stock & Bond Brokers & Dealers, Altoona
- Stocks & Bond Brokers, Altoona
- Submarine Sandwich Restaurants, Altoona
- Swimming Pool, Sauna & Spa Contractors, Altoona
- Swimming Pools, Altoona
- Swimming Pools Contractors, Altoona - Install Inground - Above Ground Pools
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