- Sand Gravel & Aggregate, Jefferson
- Sandblasting, Jefferson - General Contractors
- Sandwich Shop Restaurants, Jefferson
- Satellite TV Service, Jefferson
- Savings Banks, Jefferson
- Scrap & Waste Machinery, Jefferson
- Scrap & Waste Materials, Jefferson
- Screen Printing, Jefferson
- Secondary Schools, Jefferson
- Security Alarm Systems - Home & Business, Jefferson
- Security Brokers & Dealers, Jefferson
- Security Control Systems & Monitoring, Jefferson - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Jefferson
- Seeds & Bulbs Wholesale & Growers, Jefferson
- Senior Citizens Service & Health Organizations, Jefferson
- Septic Tank Installation & Repair, Jefferson - Septic Systems
- Septic Tank Pumping & Cleaning, Jefferson - Septic Systems
- Septic Tanks & Septic Systems Contractors, Jefferson - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewer & Drain Cleaning & Repair, Jefferson - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, Jefferson
- Sheet Metal Contractors, Jefferson - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Jefferson
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- Sheriff's Department, Jefferson
- Shoe Stores, Jefferson - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Jefferson
- Siding Contractors, Jefferson - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Jefferson
- Skating Rink & Hockey Operation Services, Jefferson
- Snacks & Desserts, Jefferson
- Snow Removal Equipment Repair & Service, Jefferson
- Social Clubs & Organizations, Jefferson
- Social Services & Welfare, Jefferson
- Societies & Foundation Associations, Jefferson
- Specialty Animal Services, Jefferson
- Specialty Stores, Jefferson
- Sporting Goods Stores, Jefferson
- State Government, Jefferson
- Stocks & Bond Brokers, Jefferson
- Stone, Jefferson
- Submarine Sandwich Restaurants, Jefferson
- Surveyor Services, Jefferson - Surveying Service
- Swimming, Jefferson
- Swimming Pools, Jefferson
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